Hacettepe Üniversitesi Eczacılık Fakültesi
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Hacettepe Üniversitesi Araştırma Öncelik Alanları RaporuHacettepe Üniversitesi Eczacılık Uygulamaları Birimi ve Ar-Ge Laboratuvarı HÜNİKALHÜEF Eczane Simülasyonu-Uygulama Eczaneleri
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Lisans Eğitimi
Lisans Eğitimi Bologna Bilgi Paketi2021-2022 Eğitim-Öğretim Yılı Önlisans, Lisans ve Lisansüstü Programlarda Eğitim-Öğretimin Yürütülmesine İlişkin Genel KurallarHacettepe Üniversitesi Uzaktan Eğitim PlatformuUlusal Eczacılık Çekirdek Eğitim ProgramıEğitim ProgramıAkademik TakvimDers ProgramıÖğrenci İşleri Daire BaşkanlığıBİLSİSYönetmeliklerAB Programları-ERASMUSÖğrenci TemsilcileriLisans Eğitimi Staj Dersleri Uygulama İlke ve EsaslarıLisans Eğitimi Staj YönergesiSınav Programları
Lisansüstü Eğitim
Farmasötik Gelişim Topluluğu (FGT)
Hacettepe University Journal of the Faculty of Pharmacy
Dış Bağlantılar
Faaliyet Raporları
Analitik Kimya Anabilim Dalı 2008 - 2018 Yılları Arasında Yayınlanan Makaleler
  1. Çelebier M, Ibáñez C, Simó C, Cifuentes A. A foodomics approach: Ce-ms for comparative metabolomics of colon cancer cells treated with dietary polyphenols. Methods in Molecular Biology: Humana Press Inc.; 2019. p. 303-13.
  2. Shammout MJA, Basci NE. Validated ultra performance liquid chromatography-tandem mass spectrometric method for determination of betamethasone or dexamethasone in pharmaceuticals. Curr Pharm Anal. 2018;14(1):68-75.
  3. Köse S, Aerts-Kaya F, Köprü ÇZ, Nemutlu E, Kuşkonmaz B, Karaosmanoğlu B, et al. Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta-adrenergic stimulation. Exp Hematol. 2018;57:30-41.e1.
  4. Ercan A, Çelebier M, Varan G, Öncül S, Nenni M, Kaplan O, et al. Global omics strategies to investigate the effect of cyclodextrin nanoparticles on MCF-7 breast cancer cells. Eur J Pharm Sci. 2018;123:377-86.
  5. Çelebier M, Koçak E, Doğan A, Altinöz S, Başci NE. Investigating the physicochemical properties of phenazopyridine hydrochloride using high-performance liquid chromatography and uv-visible spectrophotometry. Marmara Pharm J. 2018;22(4):528-35.
  6. Bayazeid O, Eylem CC, Reçber T, Yalçın FN, Kır S, Nemutlu E. An LC-ESI-MS/MS method for the simultaneous determination of pronuciferine and roemerine in some Papaver species. J Chromatogr B Anal Technol Biomed Life Sci. 2018;1096:223-7.
  7. Reçber T, Özkan E, Eren-Koçak E, Yılmaz M, Nemutlu E, Kır S. A simple extraction procedure for HPLC analysis of fluoxetine in rat plasma samples. Curr Pharm Anal. 2017;13(1):80-4.
  8. Kaynak MS, Çelebier M, Akgeyik E, Sahin S, Altınöz S. Application of HPLC to investigate the physicochemical properties and intestinal permeability of Ketoprofen. Curr Pharm Anal. 2017;13(1):72-9.
  9. Kaynak MS, Çelebier M, Akgeyik E, Sahin S, Altinöz S. Application of HPLC to investigate the physicochemical properties and intestinal permeability of ketoprofen. Curr Pharm Anal. 2017;13(1):72-9.
  10. Kaynak MS, Akgeyik E, Ateş M, Çelebier M, Sahin S. Development of HPLC methods for individual determination of 20 active pharmaceutical ingredients for ussing-chamber studies. Curr Pharm Anal. 2017;13(2):145-53.
  11. Karabey-Akyürek Y, Nemutlu E, Bilensoy E, Öner L. An improved and validated HPLC method for the determination of methylprednisolone sodium succinate and its degradation products in nanoparticles. Curr Pharm Anal. 2017;13(2):162-8.
  12. Kablan SE, Özaltın N. Investigation of electrochemical behaviour of cefuroxime axetil using hanging mercury drop electrode and graphene oxide modified glassy carbon electrode. J Electroanal Chem. 2017;785:144-51.
  13. Eroğlu H, Haidar MK, Nemutlu E, Öztürk Ş, Bayram C, Ulubayram K, et al. Dual release behavior of atorvastatin and alpha-lipoic acid from PLGA microspheres for the combination therapy in peripheral nerve injury. J Drug Deliv Sci Technol. 2017;39:455-66.
  14. Dogan A, Basci NE. Green bioanalytical and pharmaceutical analysis of voriconazole and tadalafil by HPLC. Curr Pharm Anal. 2017;13(6):495-504.
  15. Süslü İ, Çelebier M, Kablan SE, Altinöz S. Indirect square-wave voltammetric determination of cefepime in the presence of formaldehyde. Lat Am J Pharm. 2016;35(10):2246-53.
  16. Çelebier M, Reçber T, Koçak E, Altlnöz S, Klr S. Determination of Rivaroxaban in Human Plasma by Solid-Phase Extraction-High Performance Liquid Chromatography. J Chromatogr Sci. 2016;54(2):216-20.
  17. Çelebier M, Nenni M, Altınöz S. Ultrafiltration-Based Extraction and HPLC Analysis of Naproxen Sodium in Human Plasma Samples: an Innovative Approach to Pharmaceutical Analysis. Pharm Chem J. 2016;50(4):275-9.
  18. Boynueğri S, Süslü İ, Çelebier M, Altinöz S. A rapid and simple high-performance liquid chromatographic method for the analysis of ceftriaxone in perilymph fluid. Lat Am J Pharm. 2016;35(5):1001-5.
  19. Akgeyik E, Kaynak MS, Çelebier M, Altınöz S, Şahin S. Evaluation of pharmaceutical quality of conventional dosage forms containing paracetamol and caffeine available in the Turkish drug market. Diss Tech. 2016;23(2):36-41.
  20. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, et al. Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease. EBioMedicine. 2015;2(4):294-305.
  21. Yüksek H, Koca E, Gürsoy-Kol Ö, Akyildirim O, Çelebier M. Synthesis, in vitro antioxidant activity, and physicochemical properties of novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives. J Mol Liq. 2015;206:359-66.
  22. Sapmaz F, Kalkan IH, Suslu I, Demirci H, Atasoy P, Guliter S. Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus. J Dig Dis. 2015;16(9):531-6.
  23. Renkoʇlu P, Çelebier M, Arica-Yegin B. HPLC determination of olanzapine and carbamazepine in their nicotinamide cocrystals and investigation of the dissolution profiles of cocrystal tablet formulations. Pharm Dev Technol. 2015;20(3):380-4.
  24. Reçber T, Kir S. Determination of Leflunomide in Tablets by Micellar Electrokinetic Capillary Chromatography. Lat Am J Pharm. 2015;34(5):934-40.
  25. Nemutlu E, Zhang S, Xu YZ, Terzic A, Zhong L, Dzeja PD, et al. Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure. J Card Fail. 2015;21(6):460-9.
  26. Nemutlu E, Zhang S, Terzic A, Dzeja P. 18O-assisted 31P NMR and mass spectrometry for phosphometabolomic fingerprinting and metabolic monitoring. In: Grootveld M, editor. Issues in Toxicology: Royal Society of Chemistry; 2015. p. 255-86.
  27. Nemutlu E, Gupta A, Zhang S, Viqar M, Holmuhamedov E, Terzic A, et al. Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in aging myocardium. PLoS ONE. 2015;10(9).
  28. Çelebier M, Simó C, Altınöz S, Cifuentes A. Comparative proteomics to investigate the in vitro antiproliferative effect of dietary polyphenols against K562 leukemia cells. Turk J Biochem. 2015;40(2):95-104.
  29. Çelebier M, Nenni M, Dogan A, Süslü I, Altinöz S. Effect of internal standard on HPLC analysis of tablet dosage forms: An experimental study with statistical comparison. Der Pharma Chem. 2015;7(6):168-74.
  30. Çelebier M, Koçak E, Altinöz S. Evaluation of a capillary electrophoresis method for routine determination of varenicline tartrate in quality-control laboratories. Maced J Chem Chem Eng. 2015;34(2):267-75.
  31. Aydogan E, Comoglu T, Pehlivanoglu B, Dogan M, Comoglu S, Dogan A, et al. Process and formulation variables of pregabalin microspheres prepared by w/o/o double emulsion solvent diffusion method and their clinical application by animal modeling studies. Drug Dev Ind Pharm. 2015;41(8):1311-20.
  32. Yola ML, Uzun L, Özaltin N, Denizli A. Development of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods. Talanta. 2014;120:318-24.
  33. Süslü I, Çelebier M, Altinöz S. Electrochemical behaviour investigation and square-wave voltammetric determination of rivaroxaban in pharmaceutical dosage forms. Anal Methods. 2014;6(23):9397-403.
  34. Çelebier M, Kaynak MS, Altınöz S, Sahin S. UV spectrophotometric method for determination of the dissolution profile of rivaroxaban. Diss Tech. 2014;21(4):56-9.
  35. Yüksek H, Akyildirim O, Yola ML, Gürsoy-Kol O, Çelebier M, Kart D. Synthesis, in vitro antimicrobial and antioxidant activities of some new 4,5-dihydro-1h-1,2,4-triazol-5-one derivatives. Arch Pharm. 2013;346(6):470-80.
  36. Ucaktürk E, Özaltin N. Optimization of a gas chromatography-mass spectrometry method using chemometric techniques for the determination of ezetimibe in human plasma. Turk J Chem. 2013;37(5):734-45.
  37. Renda G, Yalçin FN, Nemutlu E, Akkol EK, Süntar I, Keleş H, et al. Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients. J Ethnopharmacol. 2013;148(2):423-32.
  38. Kaynak MS, Çelebier M, Sahin S, Altinöz S. Determination of in vitro dissolution profiles of amlodipine besylate and olmesartan medoxomil using a new "HPLC method". Rev Chim. 2013;64(1):27-30.
  39. Gupta VK, Yola ML, Özaltin N, Atar N, Üstündaǧ Z, Uzun L. Molecular imprinted polypyrrole modified glassy carbon electrode for the determination of tobramycin. Electrochim Acta. 2013;112:37-43.
  40. Doǧan A, Nemutlu E, Özek MA, Eroǧlu H, Kir S, Beksaç MS. The pharmacokinetic profiles of pre-operative prophylactic cefepime application in pregnant and non-pregnant women undergoing surgical interventions using a fully validated liquid chromatographic method. Chromatographia. 2013;76(21-22):1513-9.
  41. Celik H, Büyükaǧa M, Çelebier M, Turkoz Acar E, Baymak MS, Gökhan-Kelekçi N, et al. Determination of pKa values of some benzoxazoline derivatives and the structure-activity relationship. J Chem Eng Data. 2013;58(6):1589-96.
  42. Çelebier M, Süslü I, Altinöz S. Validated voltammetric determination of olmesartan medoxomil: Method development and electrochemical behaviors investigation. Anal Methods. 2013;5(5):1301-6.
  43. Çelebier M, Reçber T, Koçak E, Altinöz S. RP-HPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage forms. Bras J Pharm Sci. 2013;49(2):359-66.
  44. Altinöz S, Koçak E, Çelebier M. Validation of spectrophotometric method to quantify veranicline content in tablets. Asian J Chem. 2013;25(4):1845-8.
  45. Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease. PLoS ONE. 2012;7(2).
  46. Nemutlu E, Zhang S, Juranic NO, Terzic A, Macura S, Dzeja P. 18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases. Croat Med J. 2012;53(6):529-34.
  47. Nemutlu E, Zhang S, Gupta A, Juranic NO, Macura SI, Terzic A, et al. Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted 31P NMR and mass spectrometry. Physiol Genomics. 2012;44(7):386-402.
  48. Nemutlu E, Juranic N, Zhang S, Ward LE, Dutta T, Sreekumaran Nair K, et al. Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates. Anal Bioanal Chem. 2012;403(3):697-706.
  49. Ibáñez C, Valdés A, García-Cañas V, Simó C, Celebier M, Rocamora-Reverte L, et al. Global Foodomics strategy to investigate the health benefits of dietary constituents. J Chromatogr A. 2012;1248:139-53.
  50. Çelebier M, Ibáñez C, Simó C, Cifuentes A. A foodomics approach: CE-MS for comparative metabolomics of colon cancer cells treated with dietary polyphenols. In: Kurien BT, Scofield RH, Kurien BT, editors. Methods in Molecular Biology2012. p. 185-95.
  51. Yola ML, Özaltin N. Square-wave voltammetric determination of ezetimibe. Rev Chim. 2011;62(4):420-6.
  52. Yola ML, Özaltin N. Electrochemical studies on the interaction of an antibacterial drug nitrofurantoin with DNA. J Electroanal Chem. 2011;653(1-2):56-60.
  53. Yola ML, Özaltin N. Adsorptive stripping voltammetric methods for determination of ezetimibe in tablets. Rev Anal Chem. 2011;30(1):29-36.
  54. Süslü I, Altinöz S. Determination of glimepiride in pharmaceutical formulations by square-wave voltammetric method. Curr Anal Chem. 2011;7(4):333-40.
  55. Salman D, Dogan A, Basci NE. Spectrophotometric analysis of cabergoline in pharmaceutical preparations. Lat Am J Pharm. 2011;30(2):304.
  56. Juranić N, Nemutlu E, Zhang S, Dzeja P, Terzic A, MacUra S. 31P NMR correlation maps of 18O/16O chemical shift isotopic effects for phosphometabolite labeling studies. J Biomol NMR. 2011;50(3):237-45.
  57. Hermo MP, Nemutlu E, Barbosa J, Barrón D. Multiresidue determination of quinolones regulated by the European Union in bovine and porcine plasma. Application of chromatographic and capillary electrophoretic methodologies. Biomed Chromatogr. 2011;25(5):555-69.
  58. Dzeja PP, Hoyer K, Tian R, Zhang S, Nemutlu E, Spindler M, et al. Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J Physiol. 2011;589(21):5193-211.
  59. Dogan A, Pehlivan I, Basci NE. Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis. Lat Am J Pharm. 2011;30(1):132.
  60. Dogan A, Basci NE. Development and validation of RP-HPLC and ultraviolet spectrophotometric methods of analysis for the quantitative determination of chlorhexidine gluconate and benzydamine hydrochloride in pharmaceutical dosage forms. Curr Pharm Anal. 2011;7(3):167-75.
  61. Comoglu T, Dogan A, Comoglu S, Basci N. Formulation and evaluation of diclofenac potassium fast-disintegrating tablets and their clinical application in migraine patients. Drug Dev Ind Pharm. 2011;37(3):260-7.
  62. Çelebier M, Süslü I, Altinöz S. Simultaneous determination of olmesartan medoxomil and amlodipine besylate in pharmaceutical formulations by capillary zone electrophoresis. Lat Am J Pharm. 2011;30(4):753.
  63. Yenişehirli G, Öztaş NA, Şahin E, Çelebier M, Ancn N, Öztaş SG. Synthesis, characterization, and in vitro antimicrobial activities of organotin(IV) complexes of Schiff bases with ONO-type donor atoms. Heteroatom Chem. 2010;21(6):373-85.
  64. Yardimci C, Özaltin N. Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC. J Chromatogr Sci. 2010;48(2):95-9.
  65. Unlu N, Kocaoglan H, Sayin F, Hazirolan D, Demircan S, Basci N, et al. Penetration of topically applied diclofenac and ketorolac into the aqueous humour and subretinal fluid: Randomized clinical trial. Can J Ophthalmol. 2010;45(6):610-5.
  66. Süslü I, Özaltin N, Altinöz S. Voltammetric determination of candesartan cilexetil in Its Cu(II) complex and application to pharmaceutical formulations. J AOAC Int. 2010;93(2):562-8.
  67. Ozyuncu O, Nemutlu E, Katlan D, Kir S, Beksac MS. Maternal and fetal blood levels of moxifloxacin, levofloxacin, cefepime and cefoperazone. Int J Antimicrob Agents. 2010;36(2):175-8.
  68. Özyüncü O, Beksac MS, Nemutlu E, Katlan D, Kir S. Maternal blood and amniotic fluid levels of moxifloxacin, levofloxacin and cefixime. J Obstet Gynaecol Res. 2010;36(3):484-7.
  69. Nemutlu E, Kir S, Eroǧlu H, Katlan D, Özek A, Öyüncü O, et al. Comparison of pharmacokinetic profiles of moxifloxacin in caesarean versus non-pregnant sectioned women by fully validated HPLC with fluorescence detection. Comb Chem High Throughput Screen. 2010;13(6):502-9.
  70. Nemutlu E, Katlan D, Özyüncü Ö, Kir S, Sinan Beksaç M. Quantification of moxifloxacin and levofloxacin in curettage material by SPE-LC. Chromatographia. 2010;71(11-12):1147-50.
  71. Kayiran S, PehlIvan SB, ÇelebIer M, Ünlü N. Determination of naproxen sodium from poly(lactide-co-glycolide) corneal scaffolds. Turk J Pharm Sci. 2010;7(1):57-68.
  72. Eroglu H, Nemutlu E, Turkoglu OF, Nacar O, Bodur E, Sargon MF, et al. A quadruped study on chitosan microspheres containing atorvastatin calcium: Preparation, characterization, quantification and in-vivo application. Chem Pharm Bull. 2010;58(9):1161-7.
  73. Çelebier M, Kaynak MS, Altinöz S, Sahin S. HPLC method development for the simultaneous analysis of amlodipine and valsartan in combined dosage forms and in vitro dissolution studies. Bras J Pharm Sci. 2010;46(4):761-8.
  74. Uçaktürk E, Özaltin N, Kaya B. Quantitative analysis of ezetimibe in human plasma by gas chromatography-mass spectrometry. J Sep Sci. 2009;32(11):1868-74.
  75. Süslü I, ÖzaltIn N, AltInöz S. Square-wave adsorptive stripping voltammetric determination of candesartan cilexetil in pharmaceutical formulations. J Appl Electrochem. 2009;39(9):1535-43.
  76. Süslü I, Dinç E, Demircan S, Altinöz S. Continuous wavelet transform for the resolution of the overlapping voltammet ric signals and simultaneous determination of levodopa and benserazide. Rev Anal Chem. 2009;28(2):137-49.
  77. Nemutlu E, Kir S, Katlan D, Beksaç MS. Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: Application to validation and quantification of cefepime, cefixime and cefoperazone. Talanta. 2009;80(1):117-26.
  78. Çelebier M, Altinöz S. Application of capillary electrophoresis to investigate the degradation kinetic of olmesartan medoxomil. Lat Am J Pharm. 2009;28(1):108-11.
  79. Uǧurlu G, Özaltin N, Dinç E. Spectrophotometric determination of risedronate sodium in pharmaceutical preparations by derivative and continuous wavelet transforms. Rev Anal Chem. 2008;27(4):215-33.
  80. Süslü I, Altinöz S. Electrochemical behavior of quinapril and its determination in pharmaceutical formulations by square-wave voltammetry at a mercury electrode. Pharmazie. 2008;63(6):428-33.
  81. Palabiyik IM, Onur F, Yardimci C, Özaltin N. Simultaneous spectrophotometric determination of ezetimibe and simvastatin in pharmaceutical preparations using chemometric techniques. Quim Nova. 2008;31(5):1121-4.
  82. Nemutlu E, Kir S. Determination of the cephalosporins selected from third and forth generation in biological materials originated from human by HPLC. Hacettepe Univ J Fac Pharm. 2008;28(2):185-207.
  83. Hermo MP, Nemutlu E, Kir S, Barrón D, Barbosa J. Improved determination of quinolones in milk at their MRL levels using LC-UV, LC-FD, LC-MS and LC-MS/MS and validation in line with regulation 2002/657/EC. Anal Chim Acta. 2008;613(1):98-107.
  84. Comoglu T, Gonul N, Dogan A, Basci N. Development and in vitro evaluation of pantoprazole-loaded microspheres. Drug Deliv. 2008;15(5):295-302.
  85. Çelebier M, Kaynak MS, Altinöz S, Şahin S. Validated HPLC method development: The simultaneous analysis of amlodipine and valsartan in samples for liver perfusion studies. Hacettepe Univ J Fac Pharm. 2008;28(1):15-30.