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Department of Pharmaceutical Chemistry - Projects

Current list of projects from the last 5 years:

New Azole Compounds with Potential Antifungal and Anticonvulsant Effects: Molecular Modeling, Synthesis, and Biological Activity Studies (TÜBİTAK-1001 Project)

Studies on New Oxime Ester Derivatives with an Arylalkylazole Structure: Synthesis, Biological Activity, and Molecular Modeling (HÜBAP-Doctoral Thesis Project)

Discovery of New Alpha-Glucosidase Inhibitor Compounds Through Virtual Activity Screening of an In-House Azole Library (HÜBAP-Rapid Support Project)

Studies on Certain 5-Chloro-2-Benzoxazolinone Thiosemicarbazide, 1,3,4-Thiadiazole, and 1,2,4-Triazole-5-Thione Derivatives (HÜBAP-Master's Thesis Project)

Studies on Certain Aryloxymethyl 1,3,4-Oxadiazole, 1,3,4-Thiadiazole, and 1,2,4-Triazole and 1,2,4-Triazole-5-Thione Derivatives (HÜBAP-Rapid Support Project)

Studies on 2-Phenylbenzothiazole Derivatives (HÜBAP-Rapid Support Project)

Studies on Certain 2,3-Disubstituted-5-Methyl-4-Thiazolidinone Derivatives Expected to Show Antimycobacterial Activity (HÜBAP-Master's Thesis Project)

Anticancer Drug Design and Activity Screening (HÜBAP-International Research Collaboration Project)

Molecular Modeling, Synthesis, and Biological Activity Studies of New 2-Pyrazoline and Benzimidazole Derivatives Expected to Show Multi-Target Effects in the Treatment of Alzheimer's Disease (TÜBİTAK-1001 Project)

Synthesis of Benzimidazole Derivatives Bearing an Acrylonitrile Structure and Investigation of Their Antimycobacterial Activities (HÜBAP-Rapid Support Project)

Synthesis of New Allomaltol-Derived Mannich Bases and Evaluation of Their Tyrosinase Inhibitor Effects (HÜBAP-Rapid Support Project)

Evaluation of the Tyrosinase Inhibitor Effects of New Mannich Bases and Their Effects on Cell Viability in A375 Human Melanoma Cells (TÜBİTAK-1002 Project)

Preparation of Kojic Acid-Derived Dermocosmetic Products Effective Against Skin Blemishes (TÜBİTAK-TEYDEP-1512)

Genomic Approaches to Elucidating the Cytotoxic Effects of a Chlorokojic Acid-Derived Mannich Base on A375 Human Malignant Melanoma Cells (HÜBAP-Rapid Support Project)

Biologically Active Kojic Acid-Derived Mannich Bases (HÜBAP-Intellectual Property Rights and Patent Support Project)

Biologically Active Kojic Acid-Derived Mannich Bases-EP (HÜBAP-Intellectual Property Rights and Patent Support Project)

Kojic Acid Derived Mannich Bases with Biological Effect-US (HÜBAP-Intellectual Property Rights and Patent Support Project)

Design and Synthesis of Kojic Acid-Derived Compounds and Evaluation of Their Cytotoxicity Against Melanoma Cells and Tyrosinase Inhibition Effects (HÜBAP-Master's Thesis Project)

Synthesis of Condensed 1,4-Dihydropyridine Derivatives and Investigation of Their Calcium-Modulating Effects and Antioxidant Properties (HÜBAP-Rapid Support Project)

Synthesis of Condensed 1,4-Dihydropyridine Derivatives and Studies on Their Antimicrobial and Antioxidant Effects (HÜBAP-Rapid Support Project)

Microwave-Assisted Synthesis of L-Type Calcium Channel Blocker Condensed 1,4-Dihydropyridine Derivatives (HÜBAP-Rapid Support Project)

Synthesis and Characterization of Alkyl 2,6,6(2,7,7)-Trimethyl-4-(Biphenyl)-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylate Derivatives (HÜBAP-Rapid Support Project)

Design, Synthesis, and Determination of Inhibitor Properties of New Multi-Target Amide/Carbamate Derivatives for Use in the Treatment of Alzheimer's Disease (TÜBİTAK-1001 Project)

Synthesis of New MAO Inhibitor Compounds with a Hydrazone Structure and Evaluation of the Therapeutic Effect of MAO Inhibition in Human Prostate, Lung, and Glioma Tumors (HÜBAP-Rapid Support Project)

Synthesis, Molecular Modeling, and Investigation of MAO-A/MAO-B Selectivity of New Hydrazone Compounds Expected to Show Monoamine Oxidase Inhibitor Effects (HÜBAP-Master's Thesis Project)

Synthesis, Characterization, and Investigation of the Cytotoxic Effects of Certain New 5-Arylidene-Thiazolo[3,2-b]-1,2,4-Triazol-6(5H)-One Derivatives (TÜBİTAK-1002 Project)

Synthesis and Structure Elucidation Studies of New Compounds Bearing a Hydrazone Scaffold Expected to Show MAO Inhibitor Effects (HÜBAP-Rapid Support Project)

Synthesis and Structure Elucidation Studies of New 1-Aminomethyl-1,2,4-Triazole-5-Thione Compounds (HÜBAP-Rapid Support Project)

Investigation of the Antioxidant and Anti-Inflammatory Effects of Newly Synthesized 2-Benzoxazolinone Derivative Compounds in an Experimental Rat Acute Pancreatitis Model (HÜBAP-Rapid Support Project)

Determination of the Monoamine Oxidase (MAO) Inhibitor Activities of Newly Synthesized 2-Imino-Thiazolidin-4-One and Oxazolidinedione Derivatives (HÜBAP-Rapid Support Project)

Asymmetric Synthesis of New 2-Imino-Thiazolidin-4-One and Oxazolidinedione Derivatives and Determination of Their Antimicrobial and Monoamine Oxidase (MAO) Inhibitor Activities (TÜBİTAK-1001 Project)

Synthesis of Certain New Condensed Triazole Derivatives and Investigation of Their Anticancer Activities (HÜBAP-Doctoral Thesis Project)

Investigation of the HDAC-Specific Inhibition Activities and Neuroprotective Effects of Aryl Butenoic Acid Derivatives (HÜBAP-Comprehensive Research Project)

Synthesis and Activity Studies of New 1,2,4-Triazole Derivative Compounds That Could Be Used in the Treatment of Alzheimer's Disease (HÜBAP-Rapid Support Project)

Studies on Certain New Quinoxaline Derivatives Expected to Show EGFR Inhibitor Activity (HÜBAP-Rapid Support Project)

Evaluation of the Protective Effect of a Chlorokojic Acid-Derived Mannich Base Compound Against UV-Induced Melanoma (HÜBAP-Rapid Support Project)

Elucidation of the Cytotoxicity and Cell Death Effects of Newly Synthesized Kojic Acid Derivatives with Antityrosinase Activity on the A375 Malignant Melanoma Cell Line (HÜBAP-Master's Thesis Project)

New Drug Development and Formulation Studies for Parkinson's Disease Treatment: In Vitro/In Vivo Investigation of the Anti-Neurodegenerative and Neuroprotective Effects of KOJI MG84 and Pharmacokinetic Studies (TÜSEB-Innovative Drug Development Strategic Program)

Preformulation Studies on a Newly Synthesized 1,4-Dihydropyridine Derivative Substance Effective in Hypertension Treatment and Having Solubility Issues (HÜBAP-Rapid Support Project)

Synthesis of Potential L-/T-Type Calcium Channel Blocker Dihydropyrimidine Derivatives (HÜBAP-Rapid Support Project)

Discovery of New Antifungal Compounds Through Ligand- and Structure-Based Virtual Activity Screening Methods (HÜBAP-Rapid Support Project)

Synthesis and Characterization of New Hexahydroquinoline Derivatives, Investigation of Their Inhibitory Effects on Transforming Growth Factor Beta (TGF-β) and Anticancer Activities, and In Silico Determination of Their Interactions with Molecular Targets (HÜBAP-Comprehensive Research Project)

Synthesis and Characterization of New Hexahydroquinoline Derivatives and In Vitro and In Silico Investigation of Their Effects on Transforming Growth Factor-Beta (TGF-β) and Inflammation Mediators (HÜBAP-Rapid Support Project)

Discovery of New HIF PHD2 Inhibitors Through High-Throughput Virtual Activity Screening and Their Validation at the Cellular Level (HÜBAP-Rapid Support Project)

Development of New Candidate Molecules Targeting the YAP Protein of the Hippo Signaling Pathway for the Treatment of Hepatocellular Cancer (HÜBAP-Rapid Support Project)