HÜAFP 95-02-013-008
Serum ACE levels in lung diseases and their diagnostic significance (1996)
Project Director: Gülberk Uçar
Researchers: Ebru Ataol, Zeki Yıldırım
HÜAFP 95-02-013-002
Investigation of a-1-PI variants in emphysema (1996)
Project Director: Nilgün Sümer
Researchers: Özden Tacal
HÜAFP 96-01-301-004
Differentiation of ADA isozymes and their diagnostic significance in hemopoietic diseases.
Project Director: Gülberk Uçar
Researchers: Ebru Ataol, 1997.
TÜBİTAK SBAG-AYD 118
Determination of alpha-1-proteinase inhibitor variants in emphysema (1997)
Project Director: Nilgün Sümer
Researchers: Özden Tacal
TÜBİTAK TBAG-1395
Factors affecting the partitioning of trypsin between a1-proteinase inhibitor and a2-macroglobulin (1997)
Project Director: İnci Özer
Researchers: Nilgün Sümer, Selma (Yılmaz) Dejgaard, Oya Ortapamuk, Hilal Şimşek
TWAS 93-354 RG/BIO/AS
Ligand binding properties of a1-proteinase inhibitor
Project Director: İnci Özer, 1997.
HÜAFP 97-01-018-005
Significance of ADA isozymes in the differential diagnosis of pulmonary diseases (1998)
Project Director: Gülberk Uçar
Researchers: Ebru Ataol, Çağatay Ataol
HÜAFP 97-02-301-007
Investigation of the physical relationships between a1-proteinase inhibitor and plasma proteins (1999)
Project Director: İnci Özer
Researchers: Nilgün Sümer, Eda Baltacıoğlu, Hatice Dilsiz, Özden Tacal
TÜBİTAK SBAG-AYD-195
Determination of the substrate and inhibitor specificities of MAO isozymes (2000)
Project Director: Gülberk Uçar
Researchers: Akgül Yeşilada, Ebru Ataol
HÜAFP 97-02-301-004
Synthesis of a new group of MAO inhibitors potentially useful in the treatment of depression and Parkinson's disease, and investigation of the pharmacological and biochemical effects of these compounds (2001)
Project Director: Altan Bilgin
Researchers: Akgül Yeşilada, Gülberk Uçar, Nesrin Gökhan
HÜAFP 00-01-301-001
Effect of pre-complexation on yield in the conjugation of proteins via bifunctional cross-linkers (2002)
Project Director: İnci Özer
Researchers: Özden Tacal, Akgül Yeşilada, Berna Asal
HÜAFP 99-02-301-005
MAO isozyme levels in psychiatric diseases and their interaction with neuroleptic drugs (2003)
Project Director: Gülberk Uçar
Researchers: İrem Nemutlu Sevinç, Başaran Demir
TÜBİTAK TBAG-20-95
Purification, characterization, and investigation of the physiological effects of the scorpion venoms of Androctonus crassicauda and Mesobuthus gibbosus (BUTHIDAE)
Project Director: Aşkın Tümer
Researchers: Ali Demirsoy, Gülberk Uçar, M. Ali Onur, Canan Taş, Eda Topaloğlu, 2004.
TÜBİTAK TBAG-2124
Triarylmethane dye-protein interactions (2004)
Project Director: İnci Özer
Researchers: Özden Tacal, Yasemin Eldem, Tuba Tüylü, Fırat Ulutaş
HÜGAP Infrastructure Project 02 G-017
Synthesis, Analysis, and Investigation of the Biological Activities of Some New Hydrazone Derivative Compounds (2004)
Project Director: İnci Özer
Researchers: Akgül Yeşilada, Gülberk Uçar, Semra Koyunoğlu, Nezire Saygılı, Nilgün Sümer, Tuba Tüylü, Meral Özalp, Melike Ekizoğlu, Ekrem Kılıç, Nuran Özaltın, Emirhan Nemutlu, İncilay Süslü, Emine Yıldız
HÜGAP Directed Infrastructure Project 03-G014
Platelet Serotonin Levels in Determining Antidepressant Treatment Response in Major Depression
Project Director: Gülberk Uçar
Researchers: Başaran Demir, Eda Topaloğlu, Banu Özkan, Berna Uluğ
HÜGAP Directed Infrastructure Project 02-G050
Establishment of a Primary Cell Culture System
Project Director: Nilgün Sümer
Researchers: İnci Özer, Gülberk Uçar, Özden Tacal, Eda Topaloğlu, İrem Nemutlu
TÜBİTAK SBAG-2670 (103S009)
Effect of Ischemic Preconditioning on MAO Activity and MAO-Dependent Hydroxyl Radical Formation in Isolated Rat Lung
Project Director: Gülberk Uçar
Researchers: Bülent Gümüşel, Eda Topaloğlu, Burak Kandilci
TÜBİTAK SBAG-2912
Evaluation of the cholinesterase ligand properties of triarylmethane- and phenoxazine-based compounds (2007)
Project Director: İnci Özer
Researchers: Özden Tacal, Tuba Küçükkılınç, Yasemin Y. Yücel
TÜBİTAK SBAG-HD-3
Dye-protein interactions of triarylmethane and phenoxazine group compounds
Project Director: Nilgün Sümer
Researchers: Fırat Ulutaş
HÜBAB 07-D-01-301-001
Inhibitory effects of triarylmethane dyes on horse liver-derived glutathione S-transferase enzyme (2008)
Project Director: Gülberk Uçar
Researchers: Samiye Yabanoğlu, Specialist Biol. Yasemin Yücel Yücel
HÜBAB 0801301002 (813)
Investigation of Expression Levels of Proteins in the Multidrug Resistance and Apoptosis Pathway (2008-2011)
Project Director: Ayşe Ercan
TUBİTAK TBAG-108T232
Design of New Pyrazoline Derivatives with Monoamine Oxidase (MAO) Inhibitory Activity by Molecular Modeling, Their Synthesis, and Computational and Experimental Determination of Inhibition Kinetics (2008-2010)
Project Director: Ayşe Ercan
HÜBAB 05-D06-301-001
Investigation of the inhibitory effects of 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline derivatives on rat lung-derived semicarbazide-sensitive amine oxidase (SSAO) enzyme
Project Director: Prof. Gülberk Uçar
Researchers: Nesrin Gökhan, Samiye Yabanoğlu
HÜBAB 04-01-301-005
Interactions of triarylmethane dyes with catalase enzyme derived from horse and human erythrocytes and rat liver
Project Director: Gülberk Uçar
Researchers: Samiye Yabanoğlu, Specialist Biol. Yasemin Yücel Yücel
HÜBAB Comprehensive Research Project 05 01 301 002
Screening of natural sources for D-arabinitol dehydrogenase, recombinant enzyme production, and evaluation of its suitability for use in the diagnosis of candidiasis (2009).
Project Director: Özden Tacal, Kevser Biberoğlu, Yasemin Y. Yücel, Meral Özalp.
HÜBAB 07 D03 301 003
Synthesis of Some New Pyrazoline Derivatives and Investigation of Their Inhibitory Effects on Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase Enzymes (2009)
Project Director: Nesrin Gökhan-Kelekçi
Researchers: Umut Salgın-Gökşen, Gülberk Uçar, Samiye Yabanoğlu
HÜBAB 05-D07-101001
Could increased intestinal mucosal permeability be useful in predicting the risk of multiple organ failure in advance? (2009)
Project Director: Kaya Yorgancı
Researchers: İskender Sayek, Gülberk Uçar, Ali Konan, Samiye Yabanoğlu, İlyas Onbaşılar
HÜBAB 06 A301 001
Updating the content of the Biochemistry Laboratory course in line with the new H.U. Faculty of Pharmacy Undergraduate Education Program
Project Director: Gülberk Uçar
Researchers: İnci Özer, Nilgün Sümer, Özden Tacal, Samiye Yabanoğlu, Specialist Biol. Yasemin Yücel Yücel, Tuba Küçükkılınç
TÜBİTAK TBAG-107T783
Destabilization of Beta Amyloid Fibrils with Newly Synthesized Monoamine Oxidase (MAO) Inhibitors (2010)
Project Director: Gülberk Uçar
Researchers: Nesrin G. Kelekçi, Ayşe Ercan
Scholarship Holders: Berna Asal Altıparmak, Ömür Çelikbıçak, Samiye Yabanoğlu, Biol. Açelya Yalovaç
TEB ACADEMY 2007 RESEARCH PROJECT
Destabilization of Β-Amyloid Fibrils Formed in Alzheimer's Disease with Newly Synthesized Monoamine Oxidase (MAO) Inhibitors (2010)
Project Director: Gülberk Uçar
Researchers: Nesrin Gökhan-Kelekçi, Bekir Salih, Berna Asal Altıparmak, Ayşe Ercan, Umut Salgın Gökşen, Samiye Yabanoğlu
HÜBAB Infrastructure Project 04 A 301 006
Effect of TNF-a Blockade on Cytokine Profile in Rheumatoid Arthritis, Ankylosing Spondylitis, and Behçet's Disease (2010).
Project Director: Özden Tacal
Researchers: Kevser Biberoğlu, Tuba Küçükkılınç, İhsan Ertenli.
TÜBİTAK SBAG-3677
Investigation of structure-ligand binding relationships in human butyrylcholinesterase using a site-directed mutagenesis approach (2010).
Project Director: Özden Tacal, Hakan Akbulut, Kevser Biberoğlu.
TBAG 112T490
Preparation and Brain Targeting of Donepezil-Loaded PLGA-b-PEG Nanoparticles for Use in the Treatment of Alzheimer's Disease (2011)
Project Director: Gülberk Uçar
Researchers: Samiye Yabanoğlu-Çiftçi, Kezban Ulubayram, Banu Cahide Tel
TBAG 112T746
Synthesis of new 2-pyrazoline derivatives designed by molecular modeling, and determination of their inhibition kinetics and antidepressant activities (2011)
Project Director: Gülberk Uçar
Researchers: Nesrin Gökhan-Kelekçi, Samiye Yabanoğlu-Çiftçi, Banu Cahide Tel
TUBITAK, SBAG [110S490]
Effects of surface mutations on the inhibition and reactivation kinetics of the acetylcholinesterase enzyme (2011-2012)
Project Director: Tuba Tüylü Küçükkılınç
HÜBAB 06-01-301-003
Investigation of the effects of sodium nitrite administered prior to ischemia-reperfusion injury in the liver (2011)
Project Director: Bülent Gümüşel
Researchers: Gülberk Uçar, H. Burak Kandilci, Samiye Yabanoğlu, Petek Korkusuz
HÜBAB 012-07-301-001
The role of serotonin released by activated platelets in renal injury (2012)
Project Director: Samiye Yabanoğlu-Çiftçi
Researchers: Gülberk Uçar, Ayşe Ercan
HÜBAB 012-D06-301-002
Investigation of the protective effects of sodium nitrite, administered prior to I/R, on the inflammatory and tissue remodeling processes observed in liver injury in a mouse ischemia-reperfusion model (2012)
Project Director: Samiye Yabanoğlu-Çiftçi
Researchers: Bülent Gümüşel, Gülberk Uçar, Açelya Yalovaç
Eczacıbaşı Scientific Research and Award Fund.
Investigation of the binding sites of methylene blue and phenoxazine-based ligands on human butyrylcholinesterase by molecular modeling and site-directed mutagenesis (2013).
Project Director: Özden Tacal
Researchers: Kevser Biberoğlu, Zeynep Sezgin.
TÜBİTAK SBAG 113S256
Evaluation of the use of phenoxazine- and phenothiazine-based compounds in the treatment of Alzheimer's disease and investigation of their mechanisms of action, ongoing.
Project Director: Özden Tacal
Researchers: Gonca Akbulut, Kevser Biberoğlu, Seyhan Türk Ghasemi, Arzu Keskin Aktan