Faculty of Pharmacy
Biochemistry Department Publications
  1. Yesilada, A., Gokhan, N., Ozer, I., Vural, K., Erol, K., “5-Methyl-8-N-Substituted- thiocarbamoyl-7,8-diazobicyclo(4,3,0)non-6-enes: evaluation as BSAO Inhibitors and Pharmacological Activity Screening”, IL Farmaco 51, 775-780, 1996.
  2. Bayar, C., Ozer, I., “A Study on the Route of 1-Methyl Urate Formation in Theophylline Metabolism”, Eur. J. Metab. .Pharmacokin., 22 (4), 415-419, 1997.
  3. Ucar, G., Yildirim, Z., Ataol E., Erdogan Y. “Serum angiotensin converting enzyme activity in pulmonary diseases. Correlation with lung function parameters”, Life Sci. 61(11):1075-1082, 1997.
  4. Yildirim Z, Ucar G., Erdogan Y, Hasanoglu HC, Koksal N, Bilen S. Serum angiotensin converting enzyme in asthma. Eur. J. Respir. J., suppl. P1564, 1997.
  5. Ozer, I., “Kinetic Analysis of Enzyme Inactivation Under Second Order Conditions by Use of Substrate-to-Product Progress Curves: Application to the Inhibition of Trypsin by a1-Proteinase Inhibitor”, Anal. Biochem., 264, 199-203, 1998.
  6. Dejgaard, S., Ortapamuk, O., Ozer, I., “The Trypsin Inhibitory Efficiency of Human a2 - Macroglobulin in the Presence of a1 -Proteinase Inhibitor“, J. Enzyme Inhibition, 14, 391-405, 1999.
  7. Ozer, I., Simsek, H., “Fluorescence Monitoring of the Conformational Change in a2 - Macroglobulin Induced by Trypsin Under Second- Order Conditions : the Macroglobulin Acts Both as a Substrate and A Competitive Inhibitor of the Protease”, J. Enzyme Inhibition, 15, 101-110, 2000.
  8. Ozer, I., Tacal, O., “Method Dependence of Apparent Stoichiometry in the Binding of Salicylate Ion to Human Serum Albumin”, Anal. Biochem., 294, 1-6, 2001.
  9. Altinoz S, Ucar G, Yildiz E. Determination of rizatriptan in its tablet dosage forms by UV spectrophotometric and spectrofluorimetric methods. Anal.Lett. 35(15):2471-2485, 2002.
  10. Demir B, Ucar G, Ulug B, Ulusoy S, Sevinc I, Batur S. Platelet MAO activity in alcoholism subtypes:relationship with personality traits and executive functions. Alcohol. Alcoholism 37(6):597-602, 2002.
  11. Ucar G, Topaloglu E, Kandilci B, Gumusel B. Altered monoamine oxidase activity of lung with ischemia-reperfusion injury: effect of preconditioning. Eur. J. Biochem.269 (suppl 1):134, 2002.
  12. Tacal, O., Ozer, I., “A Comparison between SDS-PAGE and Size Exclusion Chromatography as Analytical Methods for Determining Product Composition in Protein Conjugation Reactions”, J. Biochem. Biophys. Methods, 52, 161-168, 2002.
  13. Ozer, I., Caglar, A., “Protein-Mediated Nonphotochemical Bleaching of Malachite Green in Aqueous Solution”, Dyes and Pigments, 54, 11-16, 2002.
  14. Gokhan N, Yesiada A, Ucar G, Bilgin A. 1-N-substituted thiocarbamoyl-3-phenyl-5-teteroaryl 2-pyrazolines: synthesis and evaluation as MAO inhibitors. Arch. Pharm. 336:362-371, 2003.
  15. Eldem, Y., Ozer, I., “Electrophilic Reactivity of Cationic Triarylmethane Dyes towards Proteins and Protein-Related Nucleophiles”, Dyes and Pigments, 60, 49-54, 2004.
  16. Tacal, O., Ozer, I., “Adduct-Forming Tendencies of Cationic Triarylmethane Dyes with Proteins: Metabolic and Toxicological Implications”, J. Biochem. Molec. Toxicol., 18, 253-256, 2004.
  17. Ucar G, Demir B, Ulug B. Lipid peroxidation and antioxidant enzyme activities in erythrocytes of type I and II alcoholics. Cell.Biochem.Funct. 23: 29-37, 2005.
  18. Topaloglu S, Izci E, Ozel H, Topaloglu E, Avsar FM, Saygun O, Ucar G,Sokmensuer C, Hengirmen S. Effects of TVE application during 70% hepatectomy on regeneration capacity of rats. J Surg Res 124: 139-145, 2005.
  19. Ucar G, Topaloglu E, Tas C, Tumer A. Hemolytic and catalase-inhibitory effects of the scorpion Mesobuthus gibbosus (Buthidae) venom, Toxicon 45:43-52, 2005.
  20. Ucar G, Topaloglu E, Kandilci HB, Gumusel B. Protective effect of ischemic preconditioning against oxidative stress in the isolated perfused rat lung, Clin. Biochem., 38, 681-684, 2005.
  21. Ucar G, Gokhan N, Yesilada A, Bilgin AA. 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines: A novel cholinesterase and selective monoamine oxidase B inhibitors for the treatment of Parkinson’s and Alzheimer’s diseases. Neurosci. Lett. 382, 327-331, 2005.
  22. Ucar G, Topaloglu E, Kandilci HB, Gumusel B. Elevated semicarbazide-sensitive amine oxidase (SSAO) activity in lung with ischemia-reperfusion injury: Protective effect of ischemic preconditioning plus SSAO inhibition, Life Sci 78, 421-427, 2005.
  23. Sengul N, Aslim B, Ucar G, Isik S, Yucel N, Bozkurt H, Sakaogullari Z, Atalay F, Akoglu M. Effects of exopolysaccaride (EPS)-producing probiotics in experimental colitis. Clin Nutr 23 (4), 870, 2004.
  24. Yabanoglu S, Gokhan N, Ucar G, Yesilada A. Interaction of some pyrazoline derivatives with tissue semicarbazide sensitive amine oxidase (SSAO). FEBS J, 272 (Suppl 1), 538-539, 2005.27.
  25. Ertugrul A, Ucar G, Basar K, Demir B, Yabanoglu S, Ulug B. The influence of clozapine on platelet serotonin, monoamine oxidase and plasma serotonin levels: relationship with symptoms and cognition. Eur Neuropsycopharmacol 15 (suppl 3), S462, 2005.
  26. Darilmaz G, Topaloglu S, Topaloglu E, Ozel H, Avsar FM, Sokmensuer C,Ucar G, Sahin M, Hengirmen S. Evaluation of liver damage after application of TVE in the rat model. Transplant Proc, 37, 4550-4552, 2005.
  27. Karacaoglan, V., Ozer, I., “Steady-state Kinetic Properties of Sorbitol Dehydrogenase from Chicken Liver”, Comp. Biochem. Physiol., 140(B), 309-312, 2005.
  28. Kucukkilinc, T., Ozer, I., “Inhibition of Human Plasma Cholinesterase by Malachite Green and Related Triarylmethane Dyes: Mechanistic Implications”, Arch. Biochem. Biophys., 440, 118-122, 2005.
  29. Sengul N, Aslim B, Ucar G, Yucel N, Isik S, Bozkurt H, Sakaogullari Z, Atalay F. Effects of exopolysaccharide (EPS)-producing probiotic strains on experimental colitis in rats. Dis. Colon Rec (Basimda, 2006; online yayinlandi Aralik 2005).
  30. Tacal O.,Ozer I., Inhibition of choline oxidase by quinoid dyes, J. Enzyme Inhib. Med. Chem., 21, 783-787 (2006).
  31. Ertugrul A, Ucar G, Basar K, Demir B, Yabanoglu S, Ulug B. The influence of clozapine on platelet serotonin, monoamine oxidase and plasma serotonin levels. Psychiatr Res (2006).
  32. Tacal  O., Ozer I., An assessment of the role of intracellular reductive capacity in the biological clearance of triarylmethane dyes, J. Hazard. Mater., 149, 518-522 (2007).
  33. Yucel, Y.Y., Tacal O., Ozer I., Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase, Arch. Biochem. Biophys. 478, 201-205 (2008)
  34. Bakkaloglu B, Yabanoglu S, Ozyuksel BRUcar G, Ertugrul A, Basaran D, Ulug B. Platelet and Plasma Serotonin Levels and Platelet Monoamine Oxidase Activity in Patients with Major Depression: Effects of Sertraline Treatment, Turk J Biochem 33 (3), 97-103, 2008.
  35. T Kucukkkilinc Tuylu, I Ozer. “Inhibition of electric eel acetylcholinesterase by triarylmethane dyes” Chemico-Biologico Interactions, Volume 175(1-3), Pages 309-11, 2008
  36. Jayaprakash V, Sinha BN, Ucar G, Ercan A. Pyrazoline-based mycobactin analogues as MAO-inhibitors, Bioorg Med Chem Lett 18, 6362-6368, 2008.
  37. Palaska E, Aydin F, Ucar G, Erol D. Synthesis and monoamine oxidase inhibitory activities of 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives, Archiv der Pharmazie, 341 (4), 209-215, 2008.
  38. Tacal O., Ozer I., Comparative study of the reduction of phenoxazine and phenothiazine dyes by NADH in aqueous solution, Turk J. Biochem., 34, 57-61 (2009).
  39. A.Ercan, G. Kulaksiz, O. Dalmizrak, M. Muftuoglu, H. Ogus, H., L. Cavdar, L. Inan, N. Ozer. Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease (2009). Turkish Journal of Biochemistry 34 (2), pp. 97-104
  40. Gokhan-Kelekci N, Koyunoglu S, Yabanoglu S, Yelekci K, Ozgen O, Ucar G, Erol K, Kendi E, Yesilada A. New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. Bioorg. Med. Chem. 17 (2009) 675–689, 2009.
  41. Yabanoglu S, Akkiki M, Seguelas M-H, Mialet-Perez J, Parini A, Pizzinat N. Platelet derived serotonin drives the activation of rat cardiac fibroblasts by 5-HT2A receptors, J Mol Cell Cardiology, 46:518–525, 2009.
  42. Yabanoglu S, Ucar G. The Substrate Specificity of Purified Rat Lung Semicarbazide-Sensitive Amine Oxidase (SSAO), Turc J Biochem, 34(1):2-8, 2009.
  43. Kelekci-Gokhan N, Simsek O.O, Ercan A, Yelekci K, Sahin Z.S., Isik S, Ucar G, Bilgin A.A. Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors, Bioorg Med Chem 17 (18), 6761-6772, 2009.
  44. Tacal O., Lockridge O., Methamidophos, dichlorvos, o-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry,  J. Appl. Toxicol., 30, 469-475 (2010).
  45. Sengul N, Isik S, Aslim B, Ucar G, Demirbag AE. The effect of exopolysaccharide-producing probiotic strains on gut oxidative damage in experimental colitis. Dig Dis Sci. 2011 Mar;56(3):707-14.
  46. Sahoo A, Yabanoglu S, Sinha BN, Ucar G, Basu A, Jayaprakash V. Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies. Bioorg. Med. Chem. Lett. 20:132–136, 2010.
  47. Karuppasamy M, Mahapatra M, Yabanoglu S, Ucar G, Sinha BN, Basu A, Mishra N, Sharon A, Kulandaivelu U, Jayaprakash V. Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies. Bioorg. Med. Chem. 18:1875–1881, 2010.
  48. Jayaprakash V, Yabanoglu S, Sinha BN, Ucar G. Pyrazoline-based Mycobactin Analogues as Dual Inhibitors of MAO/Cholinesterase. Turk J Biochem 35  (2) ; 91–98, 2010.
  49. T Kucukkilinc, R Cochran, J Kalisiak, E Garcia, A Valle, G Amitai, Z Radic, P. Taylor,  “Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation”, Chemico-Biologico Interactions, Volume 187 (1-3), Pages 238-240, 2010
  50. Jagrat M, Behera J, Yabanoglu S, Ercan A, Ucar G, Sinha BN, Sankaran V, Basu A, Jayaprakash V. Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4296-300.
  51. Y. Aksoy, A. Ercan, O. Dalmizrak, H. Canpinar, S.P. Kartal Durmazlar, M. Bayazit. The Determination Of Matrix Metalloproteinase 9 Activity And Gene Expression Levels In Behcet's Disease Patients With Aneurysmal Complications. (2011) Clinical Rheumatology 30 (4), pp. 515-519
  52. N. Gokhan-Kelekci, O.O. Simsek, A. Ercan, K. Yelekci, Z.S. Sahin, S. Isik, G. Ucar, A.A. Bilgin. Synthesis and Molecular Modeling of Some Novel Hexahydroindazole Derivatives As Potent Monoamine Oxidase Inhibitors. (2011) Bioorganic and Medicinal Chemistry 17 (18), pp. 6761-6772.
  53. R Cochran, J KalisiakT Kucukkilinc, Z Radic, E Garcia, L Zhang, KY Ho,  G Amitai, Z Kovarik, VV Fokin, KB Sharpless, P. Taylor, “Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging”. J Biol Chem. Volume 286(34), 29718-24, 2011
  54. Biberoglu K., Tacal O., Akbulut H., The role of Phe329 in binding of cationic triarylmethane dyes human butyrylcholinesterase, Arch. Biochem. Biophys., 511 64-68.(2011).
  55. Yalovac A, Yabanoglu Ciftci S, Gumusel B, Ucar G. Monoamine oxidase (MAO) activity and MAO-derived hydroxyl radical production in mouse model of hepatic ischemia-reperfusion Injury. Turk J Biochem 36 (3) ; 200–206, 2011.
  56. K. Senturk, O. Unsal Tan, S. Yabanoglu Ciftci, G. Ucar, E. Palaska, "Synthesis and Evaluation of Human Monoamine Oxidase Inhibitory Activities of Some 3,5-Diaryl-N-substituted-4,5-dihydro-1H-pyrazole-1-carbothioamide Derivatives", Archiv der Pharmazie , 695-702 pp., 2012 , DOI: 10.1002/ardp.201100448
  57. S. Yabanoglu Ciftci, A. YalovacR. Hekimoglu, B. Gumusel, P. KorkusuzG. Ucar, "Effects of nitrite on hepatic ischemia-reperfusion injury", Turkish Journal of Biochemistry , 391-403 pp., 2012 , DOI: 10.5505/tjb.2012.68442
  58. Biberoglu K., Schopfer LM.Tacal O., Lockridge O. (2012) The proline rich tetramerization peptides in equine serum butyrylcholinesterase. Febs J. 279(20):3844-58.
  59. Tacal  O.,  Li B., Lockridge O., Schopfer L.M (2013). Resistance of human butyrylcholinesterase to methylene blue catalyzed photoinactivation: Mass spectrometry analysis of oxidation products. Photochem. Photobiol. 89, 336-348.
  60. Sezgin Z., Biberoglu K., Chupakhin V., Makhaeva G.F., Tacal O. (2013). Determination of binding points of methylene blue and cationic phenoxazines on human butyrylcholinesterase. Arch. Biochem. Biophys. 532, 32-38.
  61. Biberoglu K., Schopfer L.M., Saxena A., Tacal O., Lockridge O (2013). Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase. Biochim. Biophys. Acta 1834, 745-53.
  62. Baysal I, Yabanoglu-Ciftci S, Tunc-Sarisozen Y, Ulubayram K, Ucar G. Interaction of selegiline-loaded PLGA-b-PEG nanoparticles with beta-amyloid fibrils. J Neural Transm. 2013 Jun;120(6):903-10.
  63. Salgin-Goksen U, Yabanoglu-Ciftci S, Ercan A, Yelekci K, Ucar G, Gokhan-Kelekci N. Evaluation of selective human MAO inhibitory activities of some novel pyrazoline derivatives. J Neural Transm. 2013 Jun;120(6):863-73.
  64. Salgin-Goksen U, Gokhan-Kelekci N, Yabanoglu-Ciftci S, Yelekci K, Ucar G. Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives. J Neural Transm. 2013 Jun;120(6):883-91.
  65. Ozturan Ozer E, Tan OU, Ozadali K, Kucukkilinc T, Balkan A, Ucar G. Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation. Bioorg Med Chem Lett. 2013 Jan 15;23(2):440-3.




  1. Adli,Z., Sumer,N., Ozer,I., Coplu,L., "A Study on serum Protease Inhibitory Capacity in Patients with Emphysema", Biyokimya Dergisi, 21, 45-57, 1996.
  2. Bayar,C., Sumer,N., "The Effect of Some Local Anesthetics on Methemoglobin Levels and Erythrocyte Enzymes", Tr. J. Med. Sci., 26, 439-443, 1996.
  3. Ortapamuk,O., Sumer,N., Ozer,I., "Irreversible Inhibition of Trypsin by The Disulphide Form of Human Alpha-1 Proteinase Inhibitor", Tr. J. Med. Sci., 26, 181-185, 1996.
  4. Ucar G. Amnion sivisi. Klin. Bil. Doktor. 7(4):573-578, 2001.
  5. Ucar G, Tas C. Cholinesterase inhibitory activities of the scorpion Mesobuthus gibbosus (Buthidae) venom peptides. FABAD J. Pharm. Sci. 28(3): 61-78, 2003.
  6. Ucar G, Demir B. Plasma semicarbazide-sensitive amine oxidase activity in type I and II alcoholics. Turk J.Biochem. 28 (4): 257-263, 2003.
  7. Ucar G. Semicarbazide-sensitive amine oxidase: biochemical and physiological properties. Turc. J. Biochem. 29: 247-254, 2004.
  8. Ucar G. Interaction of rizatriptan with rat liver monoamine oxidases. Hacettepe Universitesi Eczacilik Fakultesi Dergisi, 24, 29-40, 2004.
  9. Ucar G. Substrate specificities of monoamine oxidase isoforms. FABAD J. Pharm. Sci. 27:149-156, 2002.
  10. Ucar G, Topaloglu E, Kandilci B, Gumusel B. Increased monoamine oxidase activity of lung with ischemia-reperfusion injury: effect of preconditioning. FABAD J. Pharm. Sci. 29, 63-70, 2004.
  11. Ucar G, Gokhan N, Yesilada A, Yabanoglu S. Interaction of some 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines with rat liver semicarbazide-sensitive amine oxidase (SSAO), Hacettepe Universitesi Eczacilik Fakultesi Dergisi, 25 (1), 23-34, 2005.
  12. Ucar G, Demir B, Yabanoglu S, Ulug B. Correlation between platelet monoamine oxidase activity and serotonin content in alcoholism subtypes, FABAD J. Pharm. Sci. (In press, 2004?).
  13. Yabanoglu S, Ucar G. Monoamine oxidase and alcoholism, FABAD J. Pharm. Sci. (Basimda, 2004).
  14. Ozer, I., “Reactivity of Meldola Blue towards Sulfhydryl Groups: Analytical and Biomedical Aspects”, Turk. J. Biochem., 30, 220-224, 2005.